Psoriasis Linked With Need for Cardiovascular Interventions in Patients With Hypertension

October 18, 2018

Patients with hypertension and psoriasis more often required cardiovascular procedures and surgeries than patients with hypertension without psoriasis, according to a study published in the Journal of Dermatology.

The results suggest that patients with hypertension with concurrent psoriasis experience an earlier and more aggressive disease progression of hypertension.

“Our study alerts physicians to the likelihood that, compared with general hypertensive patients, with concurrent hypertension and psoriasis will likely require more intensive assessment for cardiovascular interventions and a more aggressive hypertensive regimen to achieve adequate control,” said senior author Tsen-Fang Tsai, MD, National Taiwan University Hospital, Taipei City, Taiwan.

Psoriasis is linked with increased risks of hypertension and cardiovascular disease, but its effect on the course of cardiovascular disease remains unknown.

To investigate, the researchers used the Taiwan National Health Insurance Research Database to identify patients with new‐onset hypertension during from 2005 to 2006. Among these patients, those with psoriasis (n = 4039) were matched in a 1:1 ratio by age and sex with patients without psoriasis. The mean follow‐up period was 5.62 years.

Psoriasis was associated with a 28% increased risk for cardiovascular procedure and surgery in patients with hypertension.

When no psoriasis served as a reference group, the adjusted hazard ratios (aHR) were higher for women than for men, and for patients aged 50 to 64 years than for younger and older patients.

Patients with severe psoriasis or psoriatic arthritis tended to have higher risks of cardiovascular procedure and surgery than patients with mild psoriasis (aHR = 1.22; 95% confidence interval [CI], 0.98-1.51) or patients without psoriatic arthritis (aHR = 1.15; 95% CI, 0.84-1.58), respectively, did, although not reaching statistical significance.